Last update
5/24/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Polyunsaturated Fat
1 g
***
Evening Primrose Oil (Seed) providing:
1300 mg
***
Linoleic Acid
949 mg
***
Gamma-Linolenic Acid
117 mg
***
Top Medical Research Studies
9
We explored how evening primrose oil might affect blood clotting in rabbits fed a high-cholesterol diet. Using a group of 40 rabbits, we supplemented their diet for 6 weeks with evening primrose oil.
The results showed promising anti-thrombotic effects. Evening primrose oil reduced cholesterol levels and improved good HDL cholesterol. Additionally, it lessened platelet adhesion to the endothelium and decreased signs of vascular damage.
Overall, we found that this dietary supplement can enhance endothelial health and may help reduce clot formation.
The results showed promising anti-thrombotic effects. Evening primrose oil reduced cholesterol levels and improved good HDL cholesterol. Additionally, it lessened platelet adhesion to the endothelium and decreased signs of vascular damage.
Overall, we found that this dietary supplement can enhance endothelial health and may help reduce clot formation.
Read More
8
Evening primrose oil reduces clotting risk
We investigated how evening primrose oil (EPO) influences blood clotting when paired with celecoxib, a medication linked to thrombotic events. Using a mouse model, we administered celecoxib alongside EPO or forskolin for four weeks, followed by a prothrombotic challenge.
Our findings suggest that while celecoxib increased thrombotic markers, the addition of EPO significantly reduced this prothrombotic effect. This indicates that EPO may help offset some negative cardiovascular impacts of celecoxib, proving its potential in clinical use.
Our findings suggest that while celecoxib increased thrombotic markers, the addition of EPO significantly reduced this prothrombotic effect. This indicates that EPO may help offset some negative cardiovascular impacts of celecoxib, proving its potential in clinical use.
Read More
8
We examined the effects of evening primrose oil (EPO) on blood platelet aggregation, a key factor in blood clot formation. Over six weeks, 40 male rabbits were divided into groups and fed either a normal diet or an atherogenic diet, with some receiving EPO.
The atherogenic diet increased platelet aggregation significantly. However, EPO supplementation notably reduced this hyperaggregation to normal levels. Additionally, it helped lower thromboxane levels and lipid peroxides, which are markers linked to clotting issues.
Overall, these findings suggest that EPO may offer protective benefits against excessive blood clotting in diets high in unhealthy fats.
The atherogenic diet increased platelet aggregation significantly. However, EPO supplementation notably reduced this hyperaggregation to normal levels. Additionally, it helped lower thromboxane levels and lipid peroxides, which are markers linked to clotting issues.
Overall, these findings suggest that EPO may offer protective benefits against excessive blood clotting in diets high in unhealthy fats.
Read More
Most Useful Reviews
7.5
Lowers cholesterol
Suitable for those over forty, this oil helps lower cholesterol and is beneficial for hair, heart, and skin. The taste is acceptable and has good quality when taken with Omega supplements.
Read More
0
Lowered blood pressure
I found that evening primrose oil significantly reduced my blood pressure to critical levels. This was particularly troubling as I have a history of low blood pressure already.
Read More
2
Incompatible with body
1 people found this helpful
This oil caused a significant drop in my blood pressure, making it unsuitable for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
9
We explored how evening primrose oil might affect blood clotting in rabbits fed a high-cholesterol diet. Using a group of 40 rabbits, we supplemented their diet for 6 weeks with evening primrose oil.
The results showed promising anti-thrombotic effects. Evening primrose oil reduced cholesterol levels and improved good HDL cholesterol. Additionally, it lessened platelet adhesion to the endothelium and decreased signs of vascular damage.
Overall, we found that this dietary supplement can enhance endothelial health and may help reduce clot formation.
The results showed promising anti-thrombotic effects. Evening primrose oil reduced cholesterol levels and improved good HDL cholesterol. Additionally, it lessened platelet adhesion to the endothelium and decreased signs of vascular damage.
Overall, we found that this dietary supplement can enhance endothelial health and may help reduce clot formation.
Read More
8
Evening primrose oil reduces clotting risk
We investigated how evening primrose oil (EPO) influences blood clotting when paired with celecoxib, a medication linked to thrombotic events. Using a mouse model, we administered celecoxib alongside EPO or forskolin for four weeks, followed by a prothrombotic challenge.
Our findings suggest that while celecoxib increased thrombotic markers, the addition of EPO significantly reduced this prothrombotic effect. This indicates that EPO may help offset some negative cardiovascular impacts of celecoxib, proving its potential in clinical use.
Our findings suggest that while celecoxib increased thrombotic markers, the addition of EPO significantly reduced this prothrombotic effect. This indicates that EPO may help offset some negative cardiovascular impacts of celecoxib, proving its potential in clinical use.
Read More
8
We investigated how evening primrose oil (EPO) affects blood clotting and blood pressure fluctuations caused by celecoxib in rats. Our study showed that celecoxib raised blood pressure and sped up blood clotting by increasing platelet activity. While EPO helped lower blood pressure and reduced platelet aggregation, omega-3 fatty acids did not have the same effect. This suggests EPO could be a helpful supplement to mitigate cardiovascular risks linked to celecoxib treatment.
Read More
8
We examined the effects of evening primrose oil (EPO) on blood platelet aggregation, a key factor in blood clot formation. Over six weeks, 40 male rabbits were divided into groups and fed either a normal diet or an atherogenic diet, with some receiving EPO.
The atherogenic diet increased platelet aggregation significantly. However, EPO supplementation notably reduced this hyperaggregation to normal levels. Additionally, it helped lower thromboxane levels and lipid peroxides, which are markers linked to clotting issues.
Overall, these findings suggest that EPO may offer protective benefits against excessive blood clotting in diets high in unhealthy fats.
The atherogenic diet increased platelet aggregation significantly. However, EPO supplementation notably reduced this hyperaggregation to normal levels. Additionally, it helped lower thromboxane levels and lipid peroxides, which are markers linked to clotting issues.
Overall, these findings suggest that EPO may offer protective benefits against excessive blood clotting in diets high in unhealthy fats.
Read More
7
Evening primrose oil shows limited effectiveness
We explored the impact of evening primrose oil (EPO) on patients with Raynaud's phenomenon (RP) by conducting a double-blind study. Initially, 21 participants received a two-week placebo course. Following this, 11 patients were given EPO for eight weeks while 10 continued with placebo. Overall, those on EPO reported fewer attacks during colder weather and reported improvements in symptoms.
However, objective measures like hand temperatures and blood flow tests didn't show significant improvement. While there were some observed antiplatelet effects and changes in platelet behavior, the treatment did not lead to marked changes in blood clotting relevant to blood flow improvement.
However, objective measures like hand temperatures and blood flow tests didn't show significant improvement. While there were some observed antiplatelet effects and changes in platelet behavior, the treatment did not lead to marked changes in blood clotting relevant to blood flow improvement.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Lowers cholesterol
Suitable for those over forty, this oil helps lower cholesterol and is beneficial for hair, heart, and skin. The taste is acceptable and has good quality when taken with Omega supplements.
Read More
0
Lowered blood pressure
I found that evening primrose oil significantly reduced my blood pressure to critical levels. This was particularly troubling as I have a history of low blood pressure already.
Read More
2
Incompatible with body
1 people found this helpful
This oil caused a significant drop in my blood pressure, making it unsuitable for me.
Read More
Frequently Asked Questions
0
Lowered blood pressure
I found that evening primrose oil significantly reduced my blood pressure to critical levels. This was particularly troubling as I have a history of low blood pressure already.
7.5
Lowers cholesterol
Suitable for those over forty, this oil helps lower cholesterol and is beneficial for hair, heart, and skin. The taste is acceptable and has good quality when taken with Omega supplements.
8
Evening primrose oil reduces clotting risk
We investigated how evening primrose oil (EPO) influences blood clotting when paired with celecoxib, a medication linked to thrombotic events. Using a mouse model, we administered celecoxib alongside EPO or forskolin for four weeks, followed by a prothrombotic challenge.
Our findings suggest that while celecoxib increased thrombotic markers, the addition of EPO significantly reduced this prothrombotic effect. This indicates that EPO may help offset some negative cardiovascular impacts of celecoxib, proving its potential in clinical use.
Our findings suggest that while celecoxib increased thrombotic markers, the addition of EPO significantly reduced this prothrombotic effect. This indicates that EPO may help offset some negative cardiovascular impacts of celecoxib, proving its potential in clinical use.
8
We investigated how evening primrose oil (EPO) affects blood clotting and blood pressure fluctuations caused by celecoxib in rats. Our study showed that celecoxib raised blood pressure and sped up blood clotting by increasing platelet activity. While EPO helped lower blood pressure and reduced platelet aggregation, omega-3 fatty acids did not have the same effect. This suggests EPO could be a helpful supplement to mitigate cardiovascular risks linked to celecoxib treatment.
9
We explored how evening primrose oil might affect blood clotting in rabbits fed a high-cholesterol diet. Using a group of 40 rabbits, we supplemented their diet for 6 weeks with evening primrose oil.
The results showed promising anti-thrombotic effects. Evening primrose oil reduced cholesterol levels and improved good HDL cholesterol. Additionally, it lessened platelet adhesion to the endothelium and decreased signs of vascular damage.
Overall, we found that this dietary supplement can enhance endothelial health and may help reduce clot formation.
The results showed promising anti-thrombotic effects. Evening primrose oil reduced cholesterol levels and improved good HDL cholesterol. Additionally, it lessened platelet adhesion to the endothelium and decreased signs of vascular damage.
Overall, we found that this dietary supplement can enhance endothelial health and may help reduce clot formation.
8
We examined the effects of evening primrose oil (EPO) on blood platelet aggregation, a key factor in blood clot formation. Over six weeks, 40 male rabbits were divided into groups and fed either a normal diet or an atherogenic diet, with some receiving EPO.
The atherogenic diet increased platelet aggregation significantly. However, EPO supplementation notably reduced this hyperaggregation to normal levels. Additionally, it helped lower thromboxane levels and lipid peroxides, which are markers linked to clotting issues.
Overall, these findings suggest that EPO may offer protective benefits against excessive blood clotting in diets high in unhealthy fats.
The atherogenic diet increased platelet aggregation significantly. However, EPO supplementation notably reduced this hyperaggregation to normal levels. Additionally, it helped lower thromboxane levels and lipid peroxides, which are markers linked to clotting issues.
Overall, these findings suggest that EPO may offer protective benefits against excessive blood clotting in diets high in unhealthy fats.
References
- Mosaad SM, Zaitone SA, Ahmed AA, Abo-Elmatty DM, El-Baz AA, et al. Evening primrose oil or forskolin ameliorates celecoxib-enhanced upregulation of tissue factor expression in mice subjected to lipopolysaccharide-induced endotoxemia. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:483. 10.1007/s00210-017-1342-y
- Zaitone SA, Moustafa YM, Mosaad SM, El-Orabi NF. Effect of evening primrose oil and ω-3 polyunsaturated fatty acids on the cardiovascular risk of celecoxib in rats. J Cardiovasc Pharmacol. 2011;58:72. 10.1097/FJC.0b013e31821c8353
- Villalobos MA, De La Cruz JP, Martín-Romero M, Carmona JA, Smith-Agreda JM, et al. Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits. Thromb Haemost. 1998;80:696. PubMed
- De La Cruz JP, Martín-Romero M, Carmona JA, Villalobos MA, Sánchez de la Cuesta F. Effect of evening primrose oil on platelet aggregation in rabbits fed an atherogenic diet. Thromb Res. 1997;87:141. PubMed
- Belch JJ, Shaw B, O'Dowd A, Saniabadi A, Leiberman P, et al. Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. Thromb Haemost. 1985;54:490. PubMed
